加尿枸橼酸盐的分泌，但作用甚微，至少在雄激素

作用的掩盖下，其抑制结石的效果可忽略不计。



　　此外，一些学者发现性激素对尿酸盐代谢也有一定的影响，如体内睾酮的下降

与胰高血糖素上升，性激素与前列腺素相互协同，据认为与门腔静脉分流术后实验

鼠尿石症几乎发生在雄性而雌性极少出现有关，其作用主要使鼠尿尿酸盐含量明显

上升，形成尿酸结石［14］。Terada等［15］认为雄雌激素相互作用可诱发组织增

生及矿物质沉积，引起膀胱结石和肿瘤。■



参考文献：



［1］Alvarez Arryo MV，Traba ML, Rapade A, et al. Role of citric acid i

n primary hyperparathyroidism with renal lithiasis. Urol Res, 1992,20∶

88-90.



［2］Spiegel AM, Pathophysiology of primary hyperparathyroidism. J Bone

Mine Res, 1991, 6∶15-17.



［3］Lindsjo M, Danielson BG, Fellstrom B, et al.Parathyroid function i

n relation to intestinal function and renal calcium reabsorption in pat

ients with nephrolithiasis. Scand J Urol Nephrol, 1991, 26∶55-64.



［4］Weisinger JR.New insights into the pathogenesis of idiopathic hype

rcalciuria:the role of bone. Kidney Int, 1996, 49∶1057-1018.



［5］Calo L,Cantaro S, Marchini F, et al. Is hydrochlorothiazide-induce

d hypocalciuria due to inhibition of prostaglandin E2 synthesis? Clin S

ci Colch, 1990,78∶321-325.



［6］Kamitsuka MD,Williams MA,Nyberg DA, et al. Renal calcification: a

complication of dexamethasone therapy in preteen infants with bronchopu

lmonary dysplasia. J Perinatal, 1995, 15∶359-363.



［7］Rizzato G, Fraioli P, Montemurro L, et al. Nephrolithiasis as a pr

esenting feature of chronic sarcoidosis. Thorax, 1995, 50∶555-559.



［8］Heilberg IP, Czepielewski MA, Ajzen H, et al. Metabolic factors fo

r urolithiasis in acromegalic patients. Braz J Med Biol Res, 1991, 24∶

687-696.



［9］Ieki Y, Miyakoshi H, Nagai Y, et al. The frequency and mechanisms

of urolithiasis in acromegaly. Nippon-Naibunpi Gakkai Zasshi, 1991, 67∶

755-763.



［10］Lee YH, Huang WC, Chiang H, et al. Determinant role of testostero

ne in the pathogenesis of urolithiasis in rats. J Urol, 1992, 147∶1134

-1138.



［11］Lee YH, Huang WC, Huang JK, et al. Testosterone enchances whereas

estrogen inhibits calcium oxalate stone formation in ethylene glycol t

reated rats. J Urol, 1996, 156∶502-505.



［12］Marcus R. Estrogens and progestins in the management of primary h

yperparathyroidism. J Bone Mine Res, 1991,2∶125-129.



［13］Kuczera M, Kiersztejn M, Kokot F, et al. Behavior of sex hormone

and genadotropin secretion in men with active nephrolithiasis. Endokryn

ol Pol, 1993, 44∶ 539-548.



［14］Schramek P, Heidenreich A, Engelmann UH, et al. Sex-dependent uro

lithiasis in the portacaval shunt rat. Part I. Urol Int, 1993, 50∶77-8

1.



［15］Terada S, Suzuki N, Uchide K, et al. Effect of testosterone on th

e development of bladder tumors and calculi in female rats. Gynecol Obs

tet Invest, 1992,34∶105-110.

相




   
     
     


转自： 仅仅学术交流与学习之用,非商业之目的.