,所用药物浓度并不能代表体内药物的实际浓度。另外,由于体外培养的细胞只是适应环境的部分细胞,而很少含氧细胞,故对药物的敏感性与体内结果仍可能有差异。体外药敏实验的实际意义就在于从目前可供选择的化疗药物中筛选出相对敏感药物,再配合合理的给药途径以达到使化疗方案个体化的目的[5]。【参考文献】 1 朱爱军,石景森.原发性胆囊癌的诊断和治疗.消化病诊断和治疗,2001,1:25. 2 Wilson JK,Sargent Jm,Eligie AW,et al.A feasibility study of chemosensitivity testing in ovarian malignancy.Br J Cancer,1990,62:189-194. 3 牟洪超,王兵.原发性胆囊癌的诊断和治疗.临床军医杂志,2003,31:93-94. 4 Garnero P,Darte C,Delmas PD.A model to monitor the efficacy of alendronate treatment in women with osteoporosis using a biochemical marker of bone turnover.Bone,1999,24:603-608. 5 Yamaue H, Tanimura H, Tsunoda T,et al.Chemosensitivity testing with highly purified fresh human tumor cells the MTT coloricmetric assay.Eur J Cancer,1991,27:1258-1263. 上一页 [1] [2]
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