n 24.0 weeks) in 24, and at 26～28 weeks (mean 27.6 weeks) in 19.The median latency periods to delivery were 72 days, 12 days, and 10 days when rupture of membranes occurred at 14～19 weeks, 20～25 weeks, and 26～28 weeks, respectively.The overall incidence of chorioamnionitis was 28%.There were no fetal deaths and nine neonatal
 deaths. When rupture of membranes occurred at 14～19 weeks, 20～25 weeks,and 26～28 weeks, the perinatal survival rates were 40%,92% and,100%, respectively. Pulmonary hypoplasia accounted for seven deaths. Of the live-born infants, 81% were alive at 2 years of corrected age. Survival without major impairment was observed in 75%, 80%, and 100% of the survivors when rupture of membranes occurred at 14～19 weeks, 20～25 weeks, and 26～28 weeks, respectively.　Conclusion: Expectant management of second-trimester PROM offers better perinatal and long-term survival than previously thought.

上一页  [1] [2]